Plasma Amino Acids | Sandor Speciality Diagnostics

Plasma Amino Acids

Overview	Indications	Applications	Reporting Benefits
Sample Requirement	Methodology	Limitations

Overview

Indication

Application

Reporting/Features

Sample Requirement

Methodology

Limitations

Plasma Amino Acid test is done postnatally, to look for the uncontrolled amount of amino acids in the blood and is a screening test

Aminoacidopathies are caused by deficiencies in enzymes involved in amino acid metabolism and are often characterized by the accumulation of toxic amino acids.
One of the confirmatory ways of diagnosing aminoacidopathies.
Can also detect low levels of any amino acid.
It happens because of the body’s inefficiency to break down or metabolize amino acids.
Early detection can help in the treatment and prevention of the condition.

Plasma Amino Acid is a follow-up test.
In newborns, it can be a follow-up after NBS-49 to confirm any amino acid disorder.
Urine organic acids detect many organic disorders such as
Cystinuria
Hartnup disease
Canavan’s disease
Neuroblastoma
Phenylketonuria
Tyrosinemia
Homocystinuria
TyrosMaple syrup urine disease, etc.inemia

Pre-symptomatic diagnosis through plasma amino acid tests can prevent the progression or the severity of the disorder.
It analyses any kind of inborn errors of metabolism associated with amino acid disorders and is an essential postnatal test as well.
Done on the liquid chromatography-mass spectrometry principle.
Covers 44 amino acid disorders.
Results are ready by the time a baby is 5–7 days old.
Potential to increase the performance metrics of testing and target disorders that may not be amenable to biochemical testing

Blood test
The amino acids are extracted from the sample, then identified and quantified by liquid chromatography-mass spectrometry.

Any kind of medication can hamper or fluctuate the result.
The sample collected from a baby still in NICU can give false results because of the ongoing treatment.
Deproteinization.