Sandor Speciality Diagnostics
Biosciences Research Services

Cyto Micro Array

Chromosomal Microarray is a DNA based genetic testing of individuals with unexplained developmental delay/intellectual disability (DD/ID), autism spectrum disorders (ASD), or multiple congenital anomalies (MCA). Used as first-tier genetic testing for detecting cytogenetic abnormalities.

Uses of SNP (Oligonucleotide) based arrays:

  • Robust Platform and chemistry
  • Detects very small Copy Number Variations
  • Platform used – Illumina

The HumanCytoSNP-12 BeadChip covers ~300,000 SNPs targeting regions shown to be important for cytogenetic analysis. The chip has a dense coverage of ~250 disease regions, including subtelomeric regions, pericentromeric regions, and sex chromosomes, commonly screened in cytogenetics labs. Sufficient SNP coverage is provided to determine dosage sensitivity of > 800 genes.

Please find attachment for more information on coverages.

The Infinium CytoSNP-850K v1.1 BeadChip according to the international community for cytogenomics studies. The gene list was defined based on content from the International Collaboration for Clinical Genomics (ICCG)1 and the Cancer Genomics Consortium (CGC). The chip SNP coverage enables copy number calls as small as 10 kb in regions associated with genetic disease. It contains approximately 850,000 empirically selected single nucleotide polymorphisms (SNPs) spanning the entire genome with enriched coverage for 3,262 genes of known cytogenetics relevance in both constitutional and cancer applications.

Please find the attachment for more information on coverage.

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